Charlie Cox should have stopped for gas in California. While he's on a cross-country trip with his teenage daughter, Joleen, his car hits empty in a creepy town in Nevada. With nary a drop of fuel to be found, Charlie and Joleen stop for the night at a dilapidated trailer park. There, Joleen catches the eye of two teenage boys, Jimmy and Pinky -- either of whom could be the serial killer currently terrorizing the town.
After breaking up with her girlfriend, a nightclub singer, Jane, answers a personal ad from Robin, a real estate agent with AIDS, seeking a cross-country travel partner. On their journey from New York City to Los Angeles, the two stop by Pittsburgh to pick up Robin's friend Holly, who is trying to escape an abusive relationship. With three distinct personalities, the women must overcome their differences to help one another.